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|Tested species reactivity||Human, Clawed frog|
|Host / Isotype||Mouse / IgG1|
|Immunogen||His-Gemin2 (starting at 2nd methionine) from SP2/0 cells|
|Contains||0.1% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-5777 detects Gemin2 in human and xenopus samples.
MA1-5777 has been successfully used in Western blot, immunoprecipitation, immunofluorescence and ELISA procedures. MA1-5777 detects a band of approximately 34 kDa.
The MA1-5777 immunogen is His-Gemin2 (starting at 2nd methionine).
Store at 4°C for one month, or in small aliquots at -20°C for longer periods.
This gene encodes one of the proteins found in the SMN complex, which consists of the suvival of motor neuron protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
component of gems 2; gem (nuclear organelle) associated protein 2; gem-associated protein 2; gemin-2; GEMIN2; SIP1-delta; SMN interacting protein 1-delta; SMN-interacting protein 1; survival of motor neuron protein interacting protein 1; Survival of motor neuron protein-interacting protein 1
GEMIN2; SIP1; SIP1-delta