This antibody is predicted to react with bovine, canine and rat based on sequence homology.
This gene encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.
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Protein Aliases: epididymis tissue sperm binding protein Li 18mP; GDH 1; GDH 2; GDH1; GDH2; GLUD; GLUD1; GLUD2; GLUDP1; glutamate dehydrogenase (NAD(P)+); glutamate dehydrogenase 1; Glutamate dehydrogenase 1, mitochondrial; glutamate dehydrogenase 2; Glutamate dehydrogenase 2, mitochondrial; glutamate dehydrogenase pseudogene 1; Memory-related gene 2 protein; MGC132003; MRG-2; testicular secretory protein Li 14
Gene Aliases: Ac2-281; AI118167; GDH; Gdh-X; GDH1; GDH2; GLUD; GLUD1; GLUD2; Gludeha; Gludl; GLUDP1; MRG-2