Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamategated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits, designated GluR-1 to -7, as well as GluR- delta2. The kainate/AMPA receptors are primarily responsible for the fast excitatory neurotransmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilon1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution. In mice, mutations in the gene encoding GluR- delta2 (GRID2) cause the Lurcher phenotype. The gene encoding human GluR- delta2 maps to chromosome 4q22.
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Protein Aliases: creeper; GDH 2; GluD2; gluR delta-2 subunit; Glutamate dehydrogenase 2, mitochondrial; glutamate dehydrogenase pseudogene 1; glutamate receptor delta-2 subunit; Glutamate Receptor Delta2 (GluD2); Glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2; hotfoot; lurcher; minisatellite 10ac detected by probe MMS10; testicular secretory protein Li 14
B230104L07Rik; cpr; GDH2; GLUD2; GLUDP1; GLURD2; GluRdelta2; GRID2; ho; Lc; Lc