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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues Y D R R L A Q H K S E I E of mGluR5.|
|Purification||Antigen affinity chromatography|
|Storage buffer||1% BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-24637 detects mGluR5 from mouse and rat samples. PA1-24637 is expected to cross react with human (100% conserved) and chicken (90% conserved) due to sequence homology.
PA1-24637 has been successfully used in Western blot procedures.
The PA1-24637 immunogen is a synthetic peptide corresponding to residues Y D R R L A Q H K S E I E of mGluR5.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
A830007B11Rik; D16Ium24; D16Ium24e; G protein coupled receptor, family C, group 1, member E; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member E; Glur-5; Glur5; Glurbeta1; glutamate receptor, metabotropic 5; metabotropic glutamate receptor (mGluR5); metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; MGC25101; protein phosphatase 1, regulatory subunit 86
6430542K11Rik; AI850523; Glu5R; GPRC1E; GRM5; mGlu5; MGLUR5; mGluR5b; PPP1R86