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This antibody is predicted to react with bovine, chicken, canine, amphibian, mouse, rabbit and rat based on sequence homology.
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is brain tissue.
Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1-3, KAI-2), which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors, which when activated can activate phopholipases or adenylylcyclase, depending on the neuron.
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Protein Aliases: bA487F5.1; dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7)); EAA4; EAA5; Excitatory amino acid receptor 4; Excitatory amino acid receptor 5; GluK2; GluK3; GluR-6; GluR-7; glutamate receptor; Glutamate receptor 6; Glutamate receptor 7; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; Glutamate receptor ionotropic, kainate 2; Glutamate receptor ionotropic, kainate 3; glutamate receptor subunit kainate subtype; glutamate receptor, ionotropic, kainate 2; glutamate receptor, ionotropic, kainate 3
Gene Aliases: GLUR6; GLUR7; GRIK2; GRIK3