This antibody is predicted to react with rat, non-human primate and rabbit based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Glucagon is a peptide hormone secreted by alpha cells in the Islet of Langerhans of the pancreas. The peptide is synthesized as a 180 amino acid precursor which is converted to glucagon by prohormone convertase 2 (PC2). The primary role of glucagon is in gluconeogenesis and glycogenolysis. It stimulates the release of glucose by converting glycogen in liver, and also maintains glucose homeostasis in coordination with insulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GCG; Glicentin; Glicentin-related polypeptide; GLP-1; GLP-1(7-36); GLP-1(7-37); GLP-2; GLP1; GLP1/2; GLP2; Glucagon; Glucagon-like peptide 1; Glucagon-like peptide 1(7-36); Glucagon-like peptide 1(7-37); Glucagon-like peptide 2; GRPP; Incretin hormone; OXM; Oxyntomodulin; preproglucagon
Gene Aliases: GCG; GLP-1; GLP1; GLP2; Glu; GRPP; PPG