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NeoBiotechnologies
Glutamate-Cysteine Ligase Regulatory Subunit Monoclonal Antibody (CPTC-GCLM-1)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
2730-MSM1-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
CPTC-GCLM-1
Immunogen
Recombinant human full-length GCLM protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
Gamma-glutamylcysteine synthetase (gamma-GCS) is the rate limiting enzyme for glutathione (L-gamma-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. Gamma-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic ntioxidants, heat shock, oxidants and cytokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: gamma glutamylcysteine synthetase; gamma-ECS regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit; GCLM; GCS light chain; glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD); glutamate-cysteine ligase modifier subunit delta2 alternative splicing; glutamate-cysteine ligase regulatory protein; GSC light chain; unnamed protein product
Gene Aliases: GLCLR
UniProt ID: (Human) P48507
Entrez Gene ID: (Human) 2730
glutamate metabolic process
glutathione biosynthetic process
response to oxidative stress
response to nutrient
response to xenobiotic stimulus
response to activity
cellular response to hepatocyte growth factor stimulus
hepatic stellate cell activation
negative regulation of neuron apoptotic process
cellular response to fibroblast growth factor stimulus
response to human chorionic gonadotropin
response to nitrosative stress
cellular response to glucose stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to thyroxine stimulus
regulation of blood vessel diameter
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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