Immunogen sequence: DRWNNTPMDE ALHFGHHDVF KILQEYQVQY TPQGDSDNGK ENQTVHKNLD GL
Sahai (1983) demonstrated phosphate-activated glutaminase (EC 220.127.116.11) in human platelets. It is the major enzyme yielding glutamate from glutamine. Significance of the enzyme derives from its possible implication in behavior disturbances in which glutamate acts as a neurotransmitter(Prusiner, 1981). High heritability of platelet glutaminase was indicated by studies of Sahai and Vogel (1983) who found an intraclass correlation coefficient of 0.96 for monozygotic twins and 0.53 for dizygotic twins.
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Protein Aliases: GLS; GLS1; glutaminase C; Glutaminase kidney isoform, mitochondrial; glutaminase, phosphate-activated; K-glutaminase; KIAA0838; L-glutamine amidohydrolase
Gene Aliases: AAD20; GAC; GAM; GLS; GLS1; KGA; KIAA0838
UniProt ID: (Human) O94925
Entrez Gene ID: (Human) 2744
Molecular Function: hydrolase