This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-28940 targets Glutamine synthetase in IHC (P) and WB applications and shows reactivity with Human, Rat, and mouse samples. For IHC, heat mediated antigen retrieval in 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0) is suggested.
The PA5-28940 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 373 of Human Glutamine synthetase.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling (Haberle et al., 2005 [PubMed 16267323]). Fetal glutamine requirements are very high and depend largely on active glutamine synthesis and the release of glutamine into the fetal circulation by the placenta. Glutamine synthetase (EC 220.127.116.11), also called glutamate-ammonia ligase (GLUL), is expressed throughout the body and plays an important role in controlling body pH and in removing ammonia from the circulation. The enzyme clears L-glutamate, the major neurotransmitter in the central nervous system, from neuronal synapses (see references in Clancy et al., 1996 [PubMed 8975719]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cell proliferation-inducing protein 59; GLNS; glutamate decarboxylase; Glutamate--ammonia ligase; glutamate-ammonia ligase (glutamine synthase); glutamate-ammonia ligase (glutamine synthetase); glutamine synthase; Glutamine synthetase; Glutamine synthetase (glutamate-ammonia ligase); glutamine synthetase 1; GS; Palmitoyltransferase GLUL; PIG43; PIG59; proliferation-inducing protein 43
Gene Aliases: GLNS; GLUL; GS; PIG43; PIG59
Molecular Function: ligase