Immunogen sequence: RVCEDFGVIA TFDPKPIPGN WNGAGCHTNF STKAMREENG LKYIEEAIEK LSKRHQYHIR AYDPKGGLDN ARRLTGFHET SNINDFSAGV ANRSASIRIP RTVGQEKKGY FEDRRPSANC DPFSVTEALI RTCLLNETG
p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 and 6 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.
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Protein Aliases: cell proliferation-inducing protein 59; GLNS; glutamate decarboxylase; Glutamate--ammonia ligase; glutamine synthase; Glutamine synthetase; GS; Palmitoyltransferase GLUL; proliferation-inducing protein 43
Gene Aliases: GLNS; GLUL; GS; PIG43; PIG59
UniProt ID: (Human) P15104
Entrez Gene ID: (Human) 2752
Molecular Function: ligase