MA5-17083 targets GPC3 in FACS, ICC, IHC, IF and WB applications and shows reactivity with Human and Mouse samples.
The MA5-17083 immunogen is purified recombinant fragment of human GPC3 expressed in E. Coli.
MA5-17083 detects GPC3 which has a predicted molecular weight of approximately 65.5kDa.
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: defective in Simpson-Golabi-Behmel overgrowth syndrome; glypican proteoglycan 3; Glypican-3; Glypican-3 alpha subunit; Glypican-3 beta subunit; GTR2-2; heparan sulphate proteoglycan; Intestinal protein OCI-5; MXR7; proteoglycan GPC3; secreted glypican-3
Gene Aliases: DGSX; GPC3; GTR2-2; MXR7; OCI-5; OCI5; SDYS; SGB; SGBS; SGBS1