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|Tested species reactivity||Human, Primate, Rhesus monkey|
|Published species reactivity||Mouse, Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified human Granzyme B.|
|Contains||0.09% sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|ELISA (ELISA)||2ug/ml - 5ug/ml|
|Flow Cytometry (Flow)||1/10 - 1/100|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 6 publications below|
Membrane permeabilization is required for flow cytometry applications. For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment.
MA1-80734 was used in flow cytometry to examine the role of GPR18 in intestinal intraepithelial lymphocytes
|Wang X,Sumida H,Cyster JG||The Journal of experimental medicine (211:2351)||2014|
Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts.
MA1-80734 was used in flow cytometry to investigate the effect of SGI-110 on cancer testis antigen gene-regulated expression
|Srivastava P,Paluch BE,Matsuzaki J,James SR,Collamat-Lai G,Karbach J,Nemeth MJ,Taverna P,Karpf AR,Griffiths EA||Leukemia research (38:1332)||2014|
Midline 1 directs lytic granule exocytosis and cytotoxicity of mouse killer T cells.
MA1-80734 was used in flow cytometry to show that MID1 regulates cytotoxic lymphocytes responses
|Boding L,Hansen AK,Meroni G,Johansen BB,Braunstein TH,Bonefeld CM,Kongsbak M,Jensen BA,Woetmann A,Thomsen AR,Odum N,von Essen MR,Geisler C||European journal of immunology (44:3109)||2014|
Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life.
MA1-80734 was used in flow cytometry to investigate incomplete immunity against intracellular pathogens in neonates
|Smith NL,Wissink E,Wang J,Pinello JF,Davenport MP,Grimson A,Rudd BD||Journal of immunology (Baltimore, Md. : 1950) (193:177)||2014|
The phenotype and activation status of regulatory T cells during Friend retrovirus infection.
MA1-80734 was used in flow cytometry to characterize the Treg populations the Friend retrovirus mouse model
|Joedicke JJ,Dietze KK,Zelinskyy G,Dittmer U||Virologica Sinica (29:48)||2014|
Early induction of polyfunctional simian immunodeficiency virus (SIV)-specific T lymphocytes and rapid disappearance of SIV from lymph nodes of sooty mangabeys during primary infection.
MA1-80734 was used in flow cytometry to study the contribution of the cellular immune response in maintaining nonpathogenic SIV infection in sooty mangabeys.
|Meythaler M,Wang Z,Martinot A,Pryputniewicz S,Kasheta M,McClure HM,O'Neil SP,Kaur A||Journal of immunology (Baltimore, Md. : 1950) (186:5151)||2011|
C11; cathepsin G-like 1; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA-1; CTLA1; CTSGL1; cytotoxic serine protease B; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin 2; fragmentin-2; granzyme 2; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); HLP; human lymphocyte protein; T-cell serine protease 1-3E
CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA1; CTSGL1; GRB; GZMB; HLP; SECT