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|Tested species reactivity||Human|
|Published species reactivity||Mouse, Rhesus monkey|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human Granzyme B.|
|Storage buffer||PBS with 10% sucrose, 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 7 publications below|
Granzyme A and granzyme B are serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. Both granzyme A and granzyme B are synthesized as inactive proenzymes, and they are stored within cytolytic granules and released by effector cells during degradation. This antibody should be useful for the localization of granzyme B-containing lytic granules and for the characterization of activated CTLs or NK cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Functional heterogeneity in the CD4+ T cell response to murine γ-herpesvirus 68.
MHGB04 was used in flow cytometry to investigate the differentiation and function of murine gamma-herpesvirus 68 (MHV-68)-specific CD4(+) T cells using gp150-specific TCR-transgenic mice
|Hu Z,Blackman MA,Kaye KM,Usherwood EJ||Journal of immunology (Baltimore, Md. : 1950) (194:2746)||2015|
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.
MHGB04 was used in flow cytometry to investigate the role of T reg cells in exhaustion of lymphocytic choriomeningitis virus-specific CD8 T cells
|Penaloza-MacMaster P,Kamphorst AO,Wieland A,Araki K,Iyer SS,West EE,O'Mara L,Yang S,Konieczny BT,Sharpe AH,Freeman GJ,Rudensky AY,Ahmed R||The Journal of experimental medicine (211:1905)||2014|
FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway.
MHGB04 was used in flow cytometry to study the effect of FTY720 treatment on CD8 T-cells
|Ntranos A,Hall O,Robinson DP,Grishkan IV,Schott JT,Tosi DM,Klein SL,Calabresi PA,Gocke AR||Journal of neuroimmunology (270:13)||2014|
|Rhesus monkey||Not Cited||
Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.
MHGB04 was used in flow cytometry to compare vaccination with highly conserved gag elements verses full-length gag DNA.
|Kulkarni V,Valentin A,Rosati M,Alicea C,Singh AK,Jalah R,Broderick KE,Sardesai NY,Le Gall S,Mothe B,Brander C,Rolland M,Mullins JI,Pavlakis GN,Felber BK||PloS one (9:null)||2014|
|Rhesus monkey||Not Cited||
IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques.
MHGB04 was used in flow cytometry to study the use of an IL-2 adjuvant when vaccinating rhesus macaques.
|Jalah R,Patel V,Kulkarni V,Rosati M,Alicea C,Ganneru B,von Gegerfelt A,Huang W,Guan Y,Broderick KE,Sardesai NY,LaBranche C,Montefiori DC,Pavlakis GN,Felber BK||Human vaccines & immunotherapeutics (8:1620)||2012|
Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection.
MHGB04 was used in flow cytometry to study TLR7 knockout mice infected with lymphocytic choriomeningitis virus.
|Walsh KB,Teijaro JR,Zuniga EI,Welch MJ,Fremgen DM,Blackburn SD,von Tiehl KF,Wherry EJ,Flavell RA,Oldstone MB||Cell host & microbe (11:643)||2012|
Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis.
MHGB04 was used in flow cytometry to elucidate the protective role of CD8(+) T cells against Histoplasma capsulatum.
|Hsieh SH,Lin JS,Huang JH,Wu SY,Chu CL,Kung JT,Wu-Hsieh BA||Infection and immunity (79:4493)||2011|
C11; cathepsin G-like 1; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA-1; CTLA1; CTSGL1; cytotoxic serine protease B; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin 2; fragmentin-2; granzyme 2; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); HLP; human lymphocyte protein; T-cell serine protease 1-3E
CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA1; CTSGL1; GRB; GZMB; HLP; SECT