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|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human Granzyme B.|
|Storage buffer||PBS with 4mg/ml BSA, sucrose|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 5 publications below|
Granzyme A and granzyme B are serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. Both granzyme A and granzyme B are synthesized as inactive proenzymes, and they are stored within cytolytic granules and released by effector cells during degradation. This antibody should be useful for the localization of granzyme B-containing lytic granules and for the characterization of activated CTLs or NK cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
MHGB05 was used in flow cytometry to evaluate as a mucosal vaccine platform against influenza A virus
|Vogel AJ,Brown DM||Frontiers in immunology (6:null)||2015|
Visualization of granzyme B-expressing CD8 T cells during primary and secondary immune responses to Listeria monocytogenes.
MHGB05 was used in flow cytometry to study CD4 and CD8 responses to L. monocytogenes using GZMB-Tom knock-in mice
|Mouchacca P,Chasson L,Frick M,Foray C,Schmitt-Verhulst AM,Boyer C||Immunology (145:24)||2015|
The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ⁺CD8αα⁺ cells.
MHGB05 was used in flow cytometry to assess the role of aryl hydrocarbon receptor nuclear translocator in intestinal intraepithelial T cells development.
|Nakajima K,Maekawa Y,Kataoka K,Ishifune C,Nishida J,Arimochi H,Kitamura A,Yoshimoto T,Tomita S,Nagahiro S,Yasutomo K||Nature communications (4:null)||2013|
Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation.
MHGB05 was used in flow cytometry to identify a new population of CD8(+)FoxP3(+) T(reg).
|Robb RJ,Lineburg KE,Kuns RD,Wilson YA,Raffelt NC,Olver SD,Varelias A,Alexander KA,Teal BE,Sparwasser T,Hammerling GJ,Markey KA,Koyama M,Clouston AD,Engwerda CR,Hill GR,MacDonald KP||Blood (119:5898)||2012|
Type I-IFNs control GVHD and GVL responses after transplantation.
MHGB05 was used in flow cytometry to study the effects of type I-interferon on graft verses host disease.
|Robb RJ,Kreijveld E,Kuns RD,Wilson YA,Olver SD,Don AL,Raffelt NC,De Weerd NA,Lineburg KE,Varelias A,Markey KA,Koyama M,Clouston AD,Hertzog PJ,Macdonald KP,Hill GR||Blood (118:3399)||2011|
C11; cathepsin G-like 1; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA-1; CTLA1; CTSGL1; cytotoxic serine protease B; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin 2; fragmentin-2; granzyme 2; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); HLP; human lymphocyte protein; T-cell serine protease 1-3E
CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA1; CTSGL1; GRB; GZMB; HLP; SECT