|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Recombinant protein encoding the N-terminus of the mature granzyme B|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:25-1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11587 targets Granzyme B in IHC (P) applications and shows reactivity with Human samples.
The MA5-11587 immunogen is recombinant protein encoding the N-terminus of the mature granzyme B.
Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified. One of these, human granzyme B, is involved in target cell apoptosis during lymphocyte-mediated cytotoxicity. Exocytosis of granzyme-containing granules in the cytoplasm of the target cell leads to the induction of DNA fragmentation and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Evidence of a pathogenic role for CD8(+) T cells in anti-GABAB receptor limbic encephalitis.
MA5-11587 was used in immunohistochemistry to characterize anti-GABAB receptor limbic encephalitis and evidence of a pathogenic role for CD8(+) T cells
|Golombeck KS,Bönte K,Mönig C,van Loo KM,Hartwig M,Schwindt W,Widman G,Lindenau M,Becker AJ,Glatzel M,Elger CE,Wiendl H,Meuth SG,Lohmann H,Gross CC,Melzer N||Neurology(R) neuroimmunology and neuroinflammation (3:null)||2016|
CD30(+) extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report.
MA5-11587 was used in immunohistochemistry to report on a case of CD30-positive extranodal natural killer/T-cell lymphoma
|Yang YJ,Li YX,Liu YB,Yang M,Liu K||Oncology letters (7:1419)||2014|
Immunohistochemical expression of granzyme B and perforin in discoid lupus erythematosus.
MA5-11587 was used in immunohistochemistry to study the clinicopathological significance of the expression of perforin and granzyme B in patients with discoid lupus erythematosus
|Abdou AG,Shoeib M,Bakry OA,El-Bality H||Ultrastructural pathology (37:408)||2013|
Clinicopathology, immunophenotype, T cell receptor gene rearrangement, Epstein-Barr virus status and p53 gene mutation of cutaneous extranodal NK/T-cell lymphoma, nasal-type.
MA5-11587 was used in immunohistochemistry to study the potential association of a range of factors with nasal type cutaneous extranodal natural killer/T-cell lymphoma
|Wang TT,Xu C,Liu SL,Kan B,Ran YP,Liu WP,Li GD,Wang L||Chinese medical journal (126:1281)||2013|
Characterization of the inflammatory response to solid cancer metastases in the human brain.
MA5-11587 was used in immunohistochemistry to study the inflammatory response to solid cancer metastases in the human brain
|Berghoff AS,Lassmann H,Preusser M,Höftberger R||Clinical and experimental metastasis (30:69)||2013|
Tumorous proliferations of plasmacytoid dendritic cells and Langerhans cells associated with acute myeloid leukaemia.
MA5-11587 was used in immunohistochemistry to study the association of tumorous proliferation of plasmacytoid dendritic cells and Langerhans cells with acute myeloid leukaemia
|Song HL,Huang WY,Chen YP,Chang KC||Histopathology (61:974)||2012|
Leukocyte composition of human breast cancer.
MA5-11587 was used in immunohistochemistry to examine tumor and nonadjacent normal breast tissue from women with breast cancer, who either had or had not received neoadjuvant chemotherapy before surgery
|Ruffell B,Au A,Rugo HS,Esserman LJ,Hwang ES,Coussens LM||Proceedings of the National Academy of Sciences of the United States of America (109:2796)||2012|
Hepatosplenic T-cell lymphoma: clinicopathologic, immunophenotypic, and molecular characterization of 17 Chinese cases.
MA5-11587 was used in immunohistochemistry to characterize seventeen clinical cases of hepatosplenic T-cell lymphoma
|Lu CL,Tang Y,Yang QP,Wang M,Zhao S,Bi CF,Jiang NG,Zhang WY,Liu JP,Xu X,Liu WP||Human pathology (42:1965)||2011|
Study of cellular immune response against Hepatitis E virus (HEV).
MA5-11587 was used in immunohistochemistry to investigate the immunopathology of hepatitis E virus infection
|Prabhu SB,Gupta P,Durgapal H,Rath S,Gupta SD,Acharya SK,Panda SK||Journal of viral hepatitis (18:587)||2011|
Aristolochic acid nephropathy revisited: a place for innate and adaptive immunity?
MA5-11587 was used in immunohistochemistry to investigate the histological features of aristolochic acid nephropathy
|Pozdzik AA,Berton A,Schmeiser HH,Missoum W,Decaestecker C,Salmon IJ,Vanherweghem JL,Nortier JL||Histopathology (56:449)||2010|
Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques.
MA5-11587 was used in immunohistochemistry to study the role of early control of immune activation in SIV infection of natural and non-natural hosts
|Estes JD,Gordon SN,Zeng M,Chahroudi AM,Dunham RM,Staprans SI,Reilly CS,Silvestri G,Haase AT||Journal of immunology (Baltimore, Md. : 1950) (180:6798)||2008|
Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia.
MA5-11587 was used in immunohistochemistry to investigate the distribution of HSV-1 immediate early genes in trigeminal ganglia and its influence on T cell function
|Derfuss T,Segerer S,Herberger S,Sinicina I,Hüfner K,Ebelt K,Knaus HG,Steiner I,Meinl E,Dornmair K,Arbusow V,Strupp M,Brandt T,Theil D||Brain pathology (Zurich, Switzerland) (17:389)||2007|
Distinct time pattern of complement activation and cytotoxic T cell response in Guillain-Barré syndrome.
MA5-11587 was used in immunohistochemistry to study the dynamics of complement activation and cytotoxic T cell responses in Guillain-Barre syndrome
|Wanschitz J,Maier H,Lassmann H,Budka H,Berger T||Brain : a journal of neurology (126:2034)||2003|
Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ?
MA5-11587 was used in immunohistochemistry - paraffin section to compare multiple sclerosis to autoimmune encephalitis in humans
|Höftberger R,Leisser M,Bauer J,Lassmann H||Acta neuropathologica communications (3:null)||2015|
Disease-specific molecular events in cortical multiple sclerosis lesions.
MA5-11587 was used in immunohistochemistry - paraffin section to investigate the mechanisms that lead to demyelination and neurodegeneration
|Fischer MT,Wimmer I,Höftberger R,Gerlach S,Haider L,Zrzavy T,Hametner S,Mahad D,Binder CJ,Krumbholz M,Bauer J,Bradl M,Lassmann H||Brain : a journal of neurology (136:1799)||2013|