|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||cDNA encoding human Granzyme K|
|Storage buffer||PBS, pH 7.2|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1.2 ug/10^6 cells|
This antibody recognizes native Granzyme K protein expressed in transfected mammalian cells.
This antibody can be used in a Sandwich ELISA as a detection antibody with Product # MA1-17754 as a capture antibody.
Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.
fragmentin-3; granzyme 3; granzyme K (granzyme 3; tryptase II); granzyme K (serine protease, granzyme 3; tryptase II); granzyme-3; GrK; NK-Tryp-2; NK-tryptase-2; tryptase II