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Invitrogen
Growth Hormone Recombinant Rabbit Monoclonal Antibody (101)
Product Details
MA5-30611
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
101
Immunogen
Recombinant Human GH1/Growth hormone 1 Protein (Phe27-Phe217)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2786320
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human GH1/Growth hormone 1.
Target Information
Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The GH1 gene, along with 4 additional related genes, is located at the growth hormone locus on chromosome 17. The five genes share a remarkably high degree of sequence identity. Alternative splicing results in 5 isoforms ranging from approximately 19 kDa to 24 kDa. HGH is produced by the somatotroph cells in the pituitary. It acts through binding to membrane receptors that belong to the cytokine receptor subfamily. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Mutations or deletions in the gene lead to growth hormone deficiency and short stature.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GH; Growth hormone; Growth hormone 1; growth hormone B5; HGH; Pituitary growth hormone; Somatotropin
Gene Aliases: GH; GH-N; GH1; GHB5; GHN; hGH-N; IGHD1B
UniProt ID: (Human) P01241
Entrez Gene ID: (Human) 2688
positive regulation of receptor internalization
JAK-STAT cascade
positive regulation of activation of JAK2 kinase activity
positive regulation of phosphatidylinositol 3-kinase signaling
glucose transport
response to estradiol
positive regulation of multicellular organism growth
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
positive regulation of MAP kinase activity
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of JAK-STAT cascade
positive regulation of peptidyl-tyrosine phosphorylation
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
bone maturation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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