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|Tested species reactivity||Not Applicable|
|Host / Isotype||E.coli|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Control (Ctrl)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Recombinant human GDF-5 is a non-glycosylated homodimer, containing two 120 amino acids chains, with a total molecular weight of 27.4 kDa. To enable bacterial expression the N-terminal sequence of Ala-Pro-Leu-Thr was replaced with a Lys. Purity is typically greater than 98% and endotoxin level less than 1 EU/ug.
The expected biological activity (ED50) is determined by the ability to induce alkaline phosphatase activity in ATDC5 cells is typically 0.1-1 ug/mL. The specific activity of this protein is 1x10^4 units/mg.
Reconstitute using sterile water at 0.1 mg/ml and centrifuge prior to opening vial. Gently pipet solution down the sides of the vial. DO NOT VORTEX sample. Store reconstituted material at -20°C and add 0.1% BSA for additional stability.
Amino acid sequence: APSATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR.
Growth/Differentiation Factor 5 (GDF-5) is a growth factor that regulates cell proliferation and differentiation in embryonic and adult tissues. GDF-5 is part of the TGF family of proteins and is closely related to the BMP family of proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
BMP-14; Bone morphogenetic protein 14; Cartilage-derived morphogenetic protein 1; cartilage-derived morphogenetic protein-1; CDMP-1; GDF-5; Growth/differentiation factor 5; H-GDF-5; LAP-4; Lipopolysaccharide-associated protein 4; LPS-associated protein 4; Radotermin
BDA1C; BMP-14; BMP14; CDMP1; GDF5; LAP-4; LAP4; OS5; SYM1B; SYNS2