In direct ELISAs, approximately 100% cross-reactivity with recombinant mouse Cadherin-13 is observed, and less than 10% cross-reactivity with recombinant human (rh) N-Cadherin is observed, and less than 2% cross-reactivity with rhCadherin-8, rhCadherin-11, rhCadherin-17, rhE-Cadherin, rhP-Cadherin, rhVE-Cadherin and rhR-Cadherin is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
The protein encoded by this gene has a C-terminal domain with tRNA 3 processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CAD13; cadherin 13, H-cadherin (heart); Cadherin-13; CD39-like 3; CD39L3; ecto-apyrase 3; ecto-ATPase 3; ecto-ATPDase 3; H-cadherin; H-cadherin (heart); Heart cadherin; heart-cadherin; NTPDase-3; P105; T cad; T Cadherin; T-cad; T-cadherin; Truncated cadherin; truncated-cadherin
Gene Aliases: CDH13; CDHH; P105
UniProt ID: (Human) P55290
Entrez Gene ID: (Human) 1012
Molecular Function: cadherin