Invitrogen

H2A.Zac pan-acetyl (K4,K7,K11,K13) Polyclonal Antibody

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H2A.Zac pan-acetyl (K4,K7,K11,K13) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of H2A.Zac pan-acetyl (K4,K7,K11, K13) in human gastric cancer and adjacent normal tissues. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-114690) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.

H2A.Zac pan-acetyl (K4,K7,K11,K13) Antibody in Western Blot (WB) — Western blot analysis of H2A.Zac pan-acetyl (K4,K7,K11, K13) in HeLa cells(TSA 1M, 18 hr.). Samples were incubated with polyclonal antibody (Product # PA5-114690).

Product Details

PA5-114690

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	-
Immunohistochemistry (PFA fixed) (IHC (PFA))	1:50-1:200	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	A synthesized peptide derived from human H2A.Z around the acetylation site of Lys4/7/11/13. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Affinity chromatography
Storage buffer	PBS with 50% glycerol, 150mM NaCl
Contains	0.02% sodium azide
Storage conditions	-20°C

Target Information

H2A.Zac pan-acetyl (K4,K7,K11,K13) is classified under histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.