MA5-15436 targets HAND1 in WB applications and shows reactivity with Human samples.
The MA5-15436 immunogen is purified recombinant fragment of HAND1 (aa90-190) expressed in E. Coli.
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.
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Protein Aliases: bHLHa27; Class A basic helix-loop-helix protein 27; eHAND; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; HAND1; Heart- and neural crest derivatives-expressed protein 1; Hxt; Thing1
Gene Aliases: BHLHA27; EHAND; HAND1; Hxt; Thing1
UniProt ID: (Human) O96004
Entrez Gene ID: (Human) 9421