Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
HAP1 Monoclonal Antibody (1B6)
Product Details
MA1-46412
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B6
Immunogen
Fusion protein from rat HAP1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS with 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2232841
Product Specific Information
In Western blot bands can be seen ~95 kDa for isoform A and ~110 kDa for isoform B.
Suggested positive control: rat brain.
Target Information
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HAP-1; HAP-1 antibody; Huntingtin-associated protein 1; huntingtin-associated protein 2; Neuroan 1
Gene Aliases: HAP-1; HAP1; HAP1-A; HAP1-B; HAP2; hHLP1; HIP5; HLP; HLP1
UniProt ID: (Human) P54257, (Rat) P54256, (Mouse) O35668
Entrez Gene ID: (Human) 9001, (Rat) 29430, (Mouse) 15114
exocytosis
autophagy
chemical synaptic transmission
brain development
anterograde axonal transport
retrograde axonal transport
protein localization
protein transport
regulation of exocytosis
cerebellum development
hypothalamus cell differentiation
cell projection organization
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
positive regulation of synaptic transmission, GABAergic
positive regulation of neurotrophin production
positive regulation of epidermal growth factor receptor signaling pathway
vesicle transport along microtubule
neurotrophin TRK receptor signaling pathway
positive regulation of neurogenesis
negative regulation of beta-amyloid formation
regulation of organelle transport along microtubule
positive regulation of nonmotile primary cilium assembly
negative regulation of cytoplasmic translation
positive regulation of neuron projection development
neuron projection development
early endosome to late endosome transport
cellular response to growth factor stimulus
positive regulation of inclusion body assembly
transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support