In Western blot bands can be seen ~95 kDa for isoform A and ~110 kDa for isoform B.
Suggested positive control: rat brain.
Huntington's disease is an autosomal dominant neurodegerative disorder caused by an expanded polyglutamine repeat region in the huntingtin gene. HAP1 is a huntingtin associated protein that shows neuronal localization and moves with huntingtin in nerve fibers. The ability of HAP1 to bind to huntingtin is enhanced by the expanded polyglutamine repeat region typical of the mutant form of the protein associated with Huntington's disease.
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Protein Aliases: HAP-1; HAP-1 antibody; Huntingtin-associated protein 1; Huntingtin-associated protein 1 antibody; huntingtin-associated protein 2; Neuroan 1
Gene Aliases: HAP-1; HAP1; HAP1-A; HAP1-B; HAP2; hHLP1; HIP5; HLP; HLP1
Molecular Function: membrane traffic protein