This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Description: This RTQ 7C3 monoclonal antibody recognizes mouse and rat HCN1. Clone RTQ 7C3 detects a ~110 kDa band corresponding to HCN1 by Western Blot.
Applications Reported: This RTQ 7C3 antibody has been reported for use in western blot.
Applications Tested: This RTQ 7C3 antibody has been tested by western blot of mouse and rat tissue lysates. This may be used at less than or equal to 1 µg/mL.
Hyperpolarization-activated cation channels of the HCN gene family such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations.
The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mammillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BCNG-1; BCNG1; Brain cyclic nucleotide gated channel 1; Brain cyclic nucleotide-gated channel 1; HAC-2; HAC2; HCN1; HCN1_HUMAN; Hyperpolarization activated cyclic nucleotide gated potassium channel 1; Hyperpolarization-activated cation channel 2; Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Gene Aliases: Bcng1; C630013B14Rik; HAC2; Hcn1