This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
MA1-25451 detects HDAC2 from human, mouse, rat, bovine, and canine samples.
MA1-25451 has been successfully used in immunoprecipitation, immunohistochemistry, ELISA, and Western blot procedures.
The MA1-25451 immunogen is a synthetic peptide, conjugated to KLH, corresponding to residues C-S(471) G E K T D T K G T K S E Q L S N P(488) of human HDAC2, with an N-terminal added cysteine.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HD2; Histone Deacetylase 2; transcriptional regulator homolog RPD3; YY1 transcription factor-binding protein; YY1-associated factor 1
Gene Aliases: BOS_9605; D10Wsu179e; HD2; HDAC2; mRPD3; RPD3; YAF1; Yy1bp