This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
MA5-15442 targets HDAC3 in IF, ChIP and WB applications and shows reactivity with Human samples.
The MA5-15442 immunogen is purified recombinant fragment of human HDAC3 (aa224-428) expressed in E. Coli.
MA5-15442 detects HDAC3 which has a predicted molecular weight of approximately 48.8kDa.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HD3; HDAC3; HDAC3 splicing HDAC3alpha; HDAC3 splicing HDAC3beta; HDAC3 splicing HDAC3delta; HDAC3 splicing HDAC3gamma; Histone deacetylase 3; RPD3; RPD3-2; SMAP45
Gene Aliases: AW537363; HD3; HDAC3; RPD3; RPD3-2