Invitrogen

HDAC5 Recombinant Rabbit Monoclonal Antibody (PSH08-70)

Advanced Verification
View all (24) HDAC5 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
HDAC5 Recombinant Rabbit Monoclonal Antibody (PSH08-70)

Product Details

MA562911

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-

Immunoprecipitation (IP)

1-2 µg
-

ChIP assay (ChIP)

0.5-2 µg/25 µg of chromatin
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

PSH08-70

Immunogen

Synthetic peptide within human HDAC5 aa 171-220.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3719766

Product Specific Information

Positive Control: Human stomach tissue, mouse stomach tissue, rat stomach tissue, HepG2, NIH/3T3, C6.

Tissue Specificity: Low tissue specificity.

Subcellular Location: Nucleus, Cytoplasm.

Sequence Similarities: 100% Mouse/Rat.

Predicted band size: 122 kDa

Target Information

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Antigen NY-CO-9; DKFZp779K1053; FLJ90614; HD5; HD7; HD7b; HD9; HDAC; HDAC-5; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; histone deacetylase 4; Histone deacetylase 5; histone deacetylase mHDA1; KIAA0744

View more View less

Gene Aliases: AI426555; HD5; Hdac4; HDAC5; KIAA0600; mHDA1; mKIAA0600; NY-CO-9

View more View less

UniProt ID: (Human) Q9UQL6

View more View less

Entrez Gene ID: (Human) 10014, (Rat) 84580, (Mouse) 15184

View more View less

Function(s)
RNA polymerase III transcription factor binding core promoter binding chromatin binding histone deacetylase activity protein kinase C binding protein binding transcription factor binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity histone deacetylase binding transcription regulatory region DNA binding metal ion binding repressing transcription factor binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding transcription corepressor activity protein kinase binding hydrolase activity histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K18 specific) histone modifying enzyme
Process(es)
negative regulation of transcription from RNA polymerase II promoter chromatin organization chromatin remodeling chromatin silencing transcription, DNA-templated protein deacetylation inflammatory response regulation of myotube differentiation negative regulation of myotube differentiation response to activity chromatin modification histone deacetylation neuron differentiation B cell differentiation cellular response to insulin stimulus regulation of gene expression, epigenetic B cell activation response to cocaine response to drug regulation of protein binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity histone H3 deacetylation cellular response to lipopolysaccharide negative regulation of cell migration involved in sprouting angiogenesis regulation of histone H3-K9 acetylation osteoblast development transcription from RNA polymerase II promoter heart development multicellular organismal response to stress negative regulation of osteoblast differentiation regulation of skeletal muscle fiber development regulation of striated muscle cell differentiation renal tubule morphogenesis cellular response to fluid shear stress positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation regulation of transcription, DNA-templated nervous system development negative regulation of gene expression negative regulation of striated muscle tissue development
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support