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|Tested species reactivity||Human, Mouse, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (8 GDAAELRKSLKPLLEKRR 25) of HES-2 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Transcription factor HES-2, of the HES family of proteins, contains one basic helix-loop-helix (bHLH) domain and one orange domain. It is reported to express in vascular smooth muscle cells, and may have some role in their differentiation. Activation of Notch signaling pathway leads to activation of Hes family genes through the interaction between Notch intracellular domain and RBPSUH (CSL). Hes family proteins are mammalian homologs of Drosophila Hairy and Enhancer of split. The Hes family of transcriptional repressors are implicated in the cell fate determination of stem cells (or precursor cells) by suppressing the expression of tissue-specific transcriptional activators.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
bHLHb40; Class B basic helix-loop-helix protein 40; Hairy and enhancer of split 2; Transcription factor HES-2
BHLHB40; HES-2; HES2