|Flow Cytometry (Flow)||1:200 - 1:400|
|Western Blot (WB)||1:500 - 1:2000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Purified recombinant fragment of human HEXA expressed in E. Coli.|
|Storage buffer||PBS with 0.5% proprietary stabilizer|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MA5-17089 targets HEXA in FACS, pep-ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17089 immunogen is purified recombinant fragment of human HEXA expressed in E. Coli.
MA5-17089 detects HEXA which has a predicted molecular weight of approximately 60.7kDa.
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Beta-hexosaminidase subunit alpha; Beta-N-acetylhexosaminidase subunit alpha; hexosaminidase A (alpha polypeptide); Hexosaminidase subunit A; N-acetyl-beta-glucosaminidase subunit alpha
Gene Aliases: Hex-1; HEXA; TSD
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