MA5-15907 targets HFE in IF and WB applications and shows reactivity with Human samples.
The MA5-15907 immunogen is purified recombinant fragment of human HFE expressed in E. Coli. .
MA5-15907 detects HFE which has a predicted molecular weight of approximately 40kDa.
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.
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Protein Aliases: Hereditary hemochromatosis protein; hereditary hemochromatosis protein HLA-H; HFE1, HH, HLA-H, MVCD7, TFQTL2, MHC class I-like protein HFE; high Fe; HLA-H; MHC class I-like protein HFE
Gene Aliases: HFE; HFE1; HH; HLA-H; HLAH; MVCD7; TFQTL2
UniProt ID: (Human) Q30201
Entrez Gene ID: (Human) 3077