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Product Details
MA5-15423
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
ELISA (ELISA) |
1:10,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
3C7B5 |
Immunogen |
Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
Conc. Not Determined |
Storage buffer |
ascites |
Contains |
0.03% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_10986466 |
Product Specific Information
MA5-15423 targets MAP4K4 in WB applications and shows reactivity with Human samples.
The MA5-15423 immunogen is purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli.
Target Information
HGK, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory protein Li 31; FLJ10410; FLJ20373; FLJ90111; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4; Nck-interacting kinase; Ste20 group protein kinase HGK
Gene Aliases: FLH21957; HEL-S-31; HGK; KIAA0687; MAP4K4; MEKKK4; NIK
UniProt ID: (Human) O95819
Entrez Gene ID: (Human) 9448
Molecular Function:
non-receptor serine/threonine protein kinase
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