|Western Blot (WB)||2 ug/ml|
|Tested Species reactivity||Bovine|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant protein derived from the C-terminus of human HIF-1-alpha protein|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
HIF-1 (hypoxia-inducible factor-1) is a heterodimer consisting of an alpha and a beta subunit, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family of transcription factors. HIF-1 is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation. HIF-1 activates transcription of hypoxia-inducible genes, including those encoding: erythropoietin, vascular endothelial growth (VEGF), heme oxygenase-1, inducible nitric oxide synthase, and the glycolytic enzymes aldolase A, enolase 1, lactate dehydrogenase A, phosphofructokinase I, and phosphoglycerate kinase 1. The C-terminal of HIF-1 alpha binds to p300. p300/CBP-HIF complexes participate in the induction of hypoxia-responsive genes, including VEGF.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha subunit (basic helix-loop-helix transcription factor); ARNT interacting protein; basic-helix-loop-helix-PAS protein MOP1; class E basic helix-loop-helix protein 78; HIF-1 alpha; HIF-1-alpha; HIF-1alpha; HIF1; HIF1 alpha; HIF1-ALPHA; hypoxia-inducible factor 1; hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha; member of PAS protein 1; member of PAS superfamily 1; MOP1; PASD8
Gene Aliases: BOS_11009
Entrez Gene ID: (Bovine) 281814
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