Product References
Activating transcription factor 4 regulates hypoxia inducible factor 1α in chronic hypoxia in pancreatic cancer cells.
Oncology reports
Chee NT,Carriere CH,Miller Z,Welford S,Brothers SP
MA1-516 was used in Gel Shift, Immunocytochemistry, Immunoelectrophoresis, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to demonstrate differential response of ATF4 in chronic hypoxia compared with acute hypoxia, and implicate this response via interaction with HIF proteins in PDAC.
Sun Jan 01 00:00:00 EST 2023
Activating transcription factor 4 regulates hypoxia inducible factor 1α in chronic hypoxia in pancreatic cancer cells.
Oncology reports
Chee NT,Carriere CH,Miller Z,Welford S,Brothers SP
MA1-516 was used in Gel Shift, Immunocytochemistry, Immunoelectrophoresis, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to demonstrate differential response of ATF4 in chronic hypoxia compared with acute hypoxia, and implicate this response via interaction with HIF proteins in PDAC.
Sun Jan 01 00:00:00 EST 2023
Low-Level Laser Therapy Induces Melanoma Tumor Growth by Promoting Angiogenesis.
Life (Basel, Switzerland)
Lin YY,Lee SY,Cheng YJ
MA1-516 was used in Gel Shift, Immunocytochemistry, Immunoelectrophoresis, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to indicate that LLLT induces melanoma tumor growth by promoting angiogenesis.
Mon Jan 23 00:00:00 EST 2023
Low-Level Laser Therapy Induces Melanoma Tumor Growth by Promoting Angiogenesis.
Life (Basel, Switzerland)
Lin YY,Lee SY,Cheng YJ
MA1-516 was used in Gel Shift, Immunocytochemistry, Immunoelectrophoresis, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to indicate that LLLT induces melanoma tumor growth by promoting angiogenesis.
Mon Jan 23 00:00:00 EST 2023
Antiangiogenic Action of JZL184 on Endothelial Cells via Inhibition of VEGF Expression in Hypoxic Lung Cancer Cells.
Cells
Wittig F,Pannenberg L,Schwarz R,Bekeschus S,Ramer R,Hinz B
Published figure using HIF1A monoclonal antibody (Product # MA1-516) in Western Blot
Fri Sep 22 00:00:00 EDT 2023
IL-17 Induces Autophagy Dysfunction to Promote Inflammatory Cell Death and Fibrosis in Keloid Fibroblasts via the STAT3 and HIF-1α Dependent Signaling Pathways.
Frontiers in immunology
Lee SY,Lee AR,Choi JW,Lee CR,Cho KH,Lee JH,Cho ML
Published figure using HIF1A monoclonal antibody (Product # MA1-516) in Immunohistochemistry
Tue Jun 28 00:00:00 EDT 2022
p53N236S Activates Autophagy in Response to Hypoxic Stress Induced by DFO.
Genes
Gao K,Zong H,Hou K,Zhang Y,Zhang R,Zhao D,Guo X,Luo Y,Jia S
MA1-516 was used in Western Blotting to show that the p53S mutant activates autophagy instead of inducing an apoptotic process in response to hypoxia stress to protect cells from death.
Tue Apr 26 00:00:00 EDT 2022
Untangling Galectin-Mediated Circuits that Control Hypoxia-Driven Angiogenesis.
Methods in molecular biology (Clifton, N.J.)
Bannoud N,García PA,Gambarte-Tudela J,Sundblad V,Cagnoni AJ,Bach CA,Pérez Saez JM,Blidner AG,Maller SM,Mariño KV,Salatino M,Cerliani JP,Rabinovich GA,Croci DO
MA1-516 was used in Gel Shift, Immunocytochemistry, Immunoelectrophoresis, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to describe selected strategies and methods used to study the role of hypoxia-regulated galectins in the regulation of blood vessel formation.
Fri Mar 25 00:00:00 EDT 2022
Untangling Galectin-Mediated Circuits that Control Hypoxia-Driven Angiogenesis.
Methods in molecular biology (Clifton, N.J.)
Bannoud N,García PA,Gambarte-Tudela J,Sundblad V,Cagnoni AJ,Bach CA,Pérez Saez JM,Blidner AG,Maller SM,Mariño KV,Salatino M,Cerliani JP,Rabinovich GA,Croci DO
MA1-516 was used in Gel Shift, Immunocytochemistry, Immunoelectrophoresis, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to describe selected strategies and methods used to study the role of hypoxia-regulated galectins in the regulation of blood vessel formation.
Fri Mar 25 00:00:00 EDT 2022
Physiological Effects of Intermittent Passive Exposure to Hypobaric Hypoxia and Cold in Rats.
Frontiers in physiology
Santocildes G,Viscor G,Pagès T,Ramos-Romero S,Torres JL,Torrella JR
MA1-516 was used in Western Blot to study the cellular response to simultaneous intermittent exposure to hypobaric hypoxia and cold.
Sat Jun 19 00:00:00 EDT 2021
Physiological Effects of Intermittent Passive Exposure to Hypobaric Hypoxia and Cold in Rats.
Frontiers in physiology
Santocildes G,Viscor G,Pagès T,Ramos-Romero S,Torres JL,Torrella JR
MA1-516 was used in Western Blot to study the cellular response to simultaneous intermittent exposure to hypobaric hypoxia and cold.
Sat Jun 19 00:00:00 EDT 2021
Arginine is neuroprotective through suppressing HIF-1α/LDHA-mediated inflammatory response after cerebral ischemia/reperfusion injury.
Molecular brain
Chen SF,Pan MX,Tang JC,Cheng J,Zhao D,Zhang Y,Liao HB,Liu R,Zhuang Y,Zhang ZF,Chen J,Lei RX,Li SF,Li HT,Wang ZF,Wan Q
MA1-516 was used in Western Blotting to indicate a possibility that arginine-induced neuroprotective effect may be through the suppression of HIF-1α/LDHA-mediated inflammatory response in microglia after cerebral ischemia injury.
Wed Apr 22 00:00:00 EDT 2020
Arginine is neuroprotective through suppressing HIF-1α/LDHA-mediated inflammatory response after cerebral ischemia/reperfusion injury.
Molecular brain
Chen SF,Pan MX,Tang JC,Cheng J,Zhao D,Zhang Y,Liao HB,Liu R,Zhuang Y,Zhang ZF,Chen J,Lei RX,Li SF,Li HT,Wang ZF,Wan Q
MA1-516 was used in Western Blotting to indicate a possibility that arginine-induced neuroprotective effect may be through the suppression of HIF-1α/LDHA-mediated inflammatory response in microglia after cerebral ischemia injury.
Wed Apr 22 00:00:00 EDT 2020
The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation.
Scientific reports
Gauthier LR,Saati M,Bensalah-Pigeon H,Ben M'Barek K,Gitton-Quent O,Bertrand R,Busso D,Mouthon MA,Collura A,Junier MP,Chneiweiss H,Pineda JR,Boussin FD
MA1-516 was used in Immunocytochemistry-immunoflourescence to show that ionizing radiation enhances the motility and invasiveness of human glioblastomas through the HIF1α/JMY pathway.
Fri Oct 30 00:00:00 EDT 2020
Flow-Encoded Oxygen Control to Track the Time-Dependence of Molecular Changes Induced by Static or Cycling Hypoxia.
Analytical chemistry
Yao M,Rabbani ZN,Sattler T,Nguyen KG,Zaharoff DA,Walker G,Gamcsik MP
MA1-516 was used in Immunohistochemistry to show how a manifold and plate design can be used to expose cells to either static or cycling hypoxic conditions for eight different time periods thereby facilitating the study of the time-response of cells to altered oxygen environments.
Tue Dec 03 00:00:00 EST 2019
Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism.
Cells
Marrocco I,Altieri F,Rubini E,Paglia G,Chichiarelli S,Giamogante F,Macone A,Perugia G,Magliocca FM,Gurtner A,Maras B,Ragno R,Patsilinakos A,Manganaro R,Eufemi M
MA1-516 was used in Western Blotting to demonstrate that in LNCaP, prostate cancer cells' SHMT2 expression is upregulated by the JAK2/STAT3 canonical pathway upon IL-6 stimulation.
Fri Sep 06 00:00:00 EDT 2019
Molecular imaging HDACs class IIa expression-activity and pharmacologic inhibition in intracerebral glioma models in rats using PET/CT/(MRI) with [18F]TFAHA.
Scientific reports
Laws MT,Bonomi RE,Kamal S,Gelovani DJ,Llaniguez J,Potukutchi S,Lu X,Mangner T,Gelovani JG
MA1-516 was used in Immunohistochemistry to demonstrate the efficacy of PET/CT/(MRI) with [18F]TFAHA for non-invasive and quantitative imaging of HDAC class IIa expression-activity in intracerebral 9L and U87-MG gliomas in rats.
Tue Mar 05 00:00:00 EST 2019
Innate immune memory in the brain shapes neurological disease hallmarks.
Nature
Wendeln AC,Degenhardt K,Kaurani L,Gertig M,Ulas T,Jain G,Wagner J,Häsler LM,Wild K,Skodras A,Blank T,Staszewski O,Datta M,Centeno TP,Capece V,Islam MR,Kerimoglu C,Staufenbiel M,Schultze JL,Beyer M,Prinz M,Jucker M,Fischer A,Neher JJ
MA1-516 was used in Immunohistochemistry-immunofluorescence to identify immune memory in the brain as an important modifier of neuropathology.
Sun Apr 01 00:00:00 EDT 2018
An Integrated Score and Nomogram Combining Clinical and Immunohistochemistry Factors to Predict High ISUP Grade Clear Cell Renal Cell Carcinoma.
Frontiers in oncology
Wu J,Xu WH,Wei Y,Qu YY,Zhang HL,Ye DW
MA1-516 was used in Immunohistochemistry to combine clinical and immunohistochemical factors for the prediction of high ISUP grade clear cell renal cell carcinoma in an attempt to improve the accuracy of a biopsy-based diagnosis.
Thu Oct 01 00:00:00 EDT 2020
Mixing and delivery of multiple controlled oxygen environments to a single multiwell culture plate.
American journal of physiology. Cell physiology
Yao M,Sattler T,Rabbani ZN,Pulliam T,Walker G,Gamcsik MP
MA1-516 was used in Immunohistochemistry-immunofluorescence to demonstrate a design which is capable of mixing and delivering differing oxygen environments to separate rows of a single multiwell culture plate.
Thu Nov 01 00:00:00 EDT 2018
Mixing and delivery of multiple controlled oxygen environments to a single multiwell culture plate.
American journal of physiology. Cell physiology
Yao M,Sattler T,Rabbani ZN,Pulliam T,Walker G,Gamcsik MP
MA1-516 was used in Immunohistochemistry-immunofluorescence to demonstrate a design which is capable of mixing and delivering differing oxygen environments to separate rows of a single multiwell culture plate.
Thu Nov 01 00:00:00 EDT 2018
STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane.
International journal of molecular sciences
Rubini E,Altieri F,Chichiarelli S,Giamogante F,Carissimi S,Paglia G,Macone A,Eufemi M
Published figure using HIF1A monoclonal antibody (Product # MA1-516) in Western Blot
Fri Jul 20 00:00:00 EDT 2018
Identification of cardiac progenitors that survive in the ischemic human heart after ventricular myocyte death.
Scientific reports
Omatsu-Kanbe M,Nozuchi N,Nishino Y,Mukaisho KI,Sugihara H,Matsuura H
MA1516 was used in immunocytochemistry to ask whether PrP+ cTnT+ cells are present in the human heart tissue with myocardial infarction
Wed Jan 25 00:00:00 EST 2017
pVHL-mediated degradation of HIF-2α regulates estrogen receptor α expression in normoxic breast cancer cells.
FEBS letters
Higashimura Y,Kitakaze T,Harada N,Inui H,Nakano Y,Yamaji R
MA1516 was used in western blot to propose that HIF-2-alpha is a negative regulator of estrogen receptor expression in breast cancer
Mon Aug 01 00:00:00 EDT 2016
A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell.
American journal of human genetics
Kulzer JR,Stitzel ML,Morken MA,Huyghe JR,Fuchsberger C,Kuusisto J,Laakso M,Boehnke M,Collins FS,Mohlke KL
MA1-516 was used in EMSA to study the upregulation of pancreatic beta cell ARAP1 by a functional regulatory DNA variant at a type 2 diabetes locus
Thu Feb 06 00:00:00 EST 2014
STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy.
Autophagy
Ferreira JV,Fôfo H,Bejarano E,Bento CF,Ramalho JS,Girão H,Pereira P
MA1-516 was used in Immunohistochemistry to show that HIF1A can be targeted for degradation in the lysosome by CMA and this targeting is dependent on its interaction with the ubiquitin ligase STUB1.
Sun Sep 01 00:00:00 EDT 2013
STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy.
Autophagy
Ferreira JV,Fôfo H,Bejarano E,Bento CF,Ramalho JS,Girão H,Pereira P
MA1-516 was used in Immunohistochemistry to show that HIF1A can be targeted for degradation in the lysosome by CMA and this targeting is dependent on its interaction with the ubiquitin ligase STUB1.
Sun Sep 01 00:00:00 EDT 2013
Human hair follicle stem/progenitor cells express hypoxia markers.
The Journal of investigative dermatology
Rathman-Josserand M,Genty G,Lecardonnel J,Chabane S,Cousson A,François Michelet J,Bernard BA
MA1-516 was used in Western Blotting to show that human hair follicles harbour two stem cell compartments that can be distinguished by differential protein expression and microenvironment.
Thu Aug 01 00:00:00 EDT 2013
Hypoxia-inducible factor and vascular endothelial growth factor are targets of dietary soy during acute stroke in female rats.
Endocrinology
Ma Y,Lovekamp-Swan T,Bekele W,Dohi A,Schreihofer DA
MA1-516 was used in western blot to study the role of HIF-1alpha and VEGF in the neuroprotective effects of soy following acute stroke
Mon Apr 01 00:00:00 EDT 2013
Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function.
Cell
Jin J,Sison K,Li C,Tian R,Wnuk M,Sung HK,Jeansson M,Zhang C,Tucholska M,Jones N,Kerjaschki D,Shibuya M,Fantus IG,Nagy A,Gerber HP,Ferrara N,Pawson T,Quaggin SE
MA1-516 was used in blocking or activating experiment to study the role of the soluble isoform of FLT-1 in modulating podocyte/pericyte function
Fri Oct 12 00:00:00 EDT 2012
Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma.
The Journal of experimental medicine
Croci DO,Salatino M,Rubinstein N,Cerliani JP,Cavallin LE,Leung HJ,Ouyang J,Ilarregui JM,Toscano MA,Domaica CI,Croci MC,Shipp MA,Mesri EA,Albini A,Rabinovich GA
MA1-516 was used in western blot to study the role of galectin-1 interactions with N-glycans in hypoxia-mediated angiogenesis and tumorigenesis in Kaposi's sarcoma
Mon Oct 22 00:00:00 EDT 2012
Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma.
The Journal of experimental medicine
Croci DO,Salatino M,Rubinstein N,Cerliani JP,Cavallin LE,Leung HJ,Ouyang J,Ilarregui JM,Toscano MA,Domaica CI,Croci MC,Shipp MA,Mesri EA,Albini A,Rabinovich GA
MA1-516 was used in western blot to study the role of galectin-1 interactions with N-glycans in hypoxia-mediated angiogenesis and tumorigenesis in Kaposi's sarcoma
Mon Oct 22 00:00:00 EDT 2012
Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells.
Archives of biochemistry and biophysics
Higashimura Y,Nakajima Y,Yamaji R,Harada N,Shibasaki F,Nakano Y,Inui H
MA1-516 was used in western blot to investigate the effect of HIF-1 on the regulation of GAPDH expression in hypoxic breast cancer cells
Sun May 01 00:00:00 EDT 2011
Hypoxia preconditioning protection of corneal stromal cells requires HIF1alpha but not VEGF.
Molecular vision
Xing D,Bonanno JA
MA1-516 was used in western blot to investigate the role of HIF-1alpha on hypoxia preconditioning protection in corneal stromal cells
Mon May 18 00:00:00 EDT 2009
Hypoxia upregulates carcinoembryonic antigen expression in cancer cells.
International journal of cancer
Kokkonen N,Ulibarri IF,Kauppila A,Luosujärvi H,Rivinoja A,Pospiech H,Kellokumpu I,Kellokumpu S
MA1-516 was used in western blot to study the upregulation of carcinoembryonic antigen expression in cancer cells by hypoxia
Sat Dec 01 00:00:00 EST 2007
Hypoxia preconditioning protects corneal stromal cells against induced apoptosis.
Experimental eye research
Xing D,Sun X,Li J,Cui M,Tan-Allen K,Bonanno JA
MA1-516 was used in western blot to investigate the influence of hypoxia on corneal stromal cell survival
Mon May 01 00:00:00 EDT 2006
Role of oxygen and vascular development in epithelial branching morphogenesis of the developing mouse lung.
American journal of physiology. Lung cellular and molecular physiology
van Tuyl M,Liu J,Wang J,Kuliszewski M,Tibboel D,Post M
MA1-516 was used in western blot to study the effect of oxygen level during mouse lung development
Sat Jan 01 00:00:00 EST 2005
Experimental angiogenesis of arterial vasa vasorum.
Cell and tissue research
Bayer IM,Caniggia I,Adamson SL,Langille BL
MA1-516 was used in immunohistochemistry to study the development of arterial vasa vasorum in a rabbit model
Fri Mar 01 00:00:00 EST 2002
Angiogenic potential of prostate carcinoma cells overexpressing bcl-2.
Journal of the National Cancer Institute
Fernandez A,Udagawa T,Schwesinger C,Beecken W,Achilles-Gerte E,McDonnell T,D'Amato R
MA1-516 was used in western blot to investigate the role of bcl-2 in tumorigenesis
Wed Feb 07 00:00:00 EST 2001