Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Proteintech
Immunogen sequence: MTADKEKKR SSSERRKEKS RDAARCRRSK ETEVFYELAH ELPLPHSVSS HLDKASIMRL AISFLRTHKL LSSVCSENES EAEADQQMDN LYLKALEGFI AVVTQDGDMI FLSENISKFM GLTQVELTGH SIFDFTHPCD HEEIRENLSL KNGSGFGKKS KDMSTERDFF MRMKCTVTNR GRTVNLKSAT WKVLHCTGQV KVYNNCPPHN SLCGYKEPLL SCLIIMCEPI QHPSHMDIPL DSKTFLSRHS MDMKFTYCDD RITELIGYHP EELLGRSAYE FYHALDSENM TKSHQNLCTK GQVVSGQYRM LAKHGGYVWL ETQGTVIYNP RNLQPQCIMC VNYVLSEIEK N
HIF-2 alpha (Epas1) is a transcription factor involved in the induction of genes regulated by oxygen. HIF-2 alpha contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. It also regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of the lungs. Mutations in this gene are associated with erythrocytosis familial type 4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; Endothelial PAS domain-containing protein 1; EPAS-1; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF-2 alpha; HIF-2-alpha; HIF2 alpha; HIF2-alpha; HLF; hypoxia inducible factor 2, alpha subunit; hypoxia inducible factor 2a; hypoxia-inducible factor 2 alpha; Hypoxia-inducible factor 2-alpha; Member of PAS protein 2; PAS domain-containing protein 2
Gene Aliases: BHLHE73; ECYT4; EPAS1; HIF2A; HLF; MOP2; PASD2
UniProt ID: (Human) Q99814, (Rat) Q9JHS1
Entrez Gene ID: (Human) 2034, (Rat) 29452
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