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Histogram overlay plot of gated human lymphocytes, the black line represents cells labeled with HLA-DR Mouse Anti-Human mAb (clone Tu36), Qdot® 705 Conjugate and the gray line represents unstained cells. Samples were acquired and analyzed using 405 nm excitation and a 695/40 band pass emission filter using the Attune® Acoustic Cytometer Blue/Violet option (Life Technologies, Carlsbad CA).
|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Storage buffer||0.05M borate, pH 8.3, with 1M betaine|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
DASS-397D15.1; DR alpha chain; FLJ51114; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen; HLA-DRA1; MHC cell surface glycoprotein; MHC class II antigen DRA; MLRW
HLA-DRA; HLA-DRA1; MLRW