HLA-F belongs to the HLA class I heavy chain paralogues. It is a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CDA12; HLA class I histocompatibility antigen, alpha chain F; HLA class I molecule; HLA F antigen; Leukocyte antigen F; MHC class I antigen F; MHC class Ib antigen
Gene Aliases: CDA12; HLA-5.4; HLA-CDA12; HLA-F; HLAF
UniProt ID: (Human) P30511
Entrez Gene ID: (Human) 3134