Positive Control: 293T, A431, HeLa, HepG2, A375, mouse brain, rat brain
Predicted Reactivity: Xenopus laevis (87%), Pig (99%), Chicken (92%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
HMGB1/HMGB2 encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Amphoterin; Heparin-binding protein p30; high mobility group 1; High mobility group protein 1; High mobility group protein 2; High mobility group protein B1; High mobility group protein B2; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group (nonhistone chromosomal) protein 2; high-mobility group box 1; high-mobility group box 2; HMG-1; HMG-2; HMG2; HMGB2; Sulfoglucuronyl carbohydrate binding protein
Gene Aliases: Ac2-008; amphoterin; C80539; DEF; HMG-1; HMG-2; HMG1; HMG2; HMG3; HMGB1; HMGB2; p30; SBP-1