Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene.
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Protein Aliases: heme oxygenase (decycling) 2; Heme oxygenase 2; HMOX 2; HO 2; HO-2
Gene Aliases: HMOX2; HO-2; HO2
UniProt ID: (Human) P30519
Entrez Gene ID: (Human) 3163
Molecular Function: oxygenase