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|Tested species reactivity||Hamster, Human, Mouse, Rat, Clawed frog|
|Host / Isotype||Mouse / IgG|
|Immunogen||Fusion protein corresponding to residues 109-269 of human TCF1.|
|Storage buffer||0.1M tris glycine, pH 7.4, with 0.15M NaCl, 30% glycerol|
|Contains||0.08% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Western Blot (WB)||0.5-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-25417 detects HNF1 from human samples. MA1-25417 is expected to cross react with mouse (100% conserved), rat (100% conserved), Xenopus laevis (86% conserved), chicken (99% conserved), and hamster (99% conserved) due to sequence homology.
MA1-25417 has been successfully used in Western blot and immunohistochemistry (frozen) procedures.
The MA1-25417 immunogen is a fusion protein corresponding to residues 109-269 of human TCF1.
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
albumin proximal factor; hepatic nuclear factor 1; hepatic nuclear factor-1-alpha; hepatocyte nuclear factor 1; Hepatocyte nuclear factor 1-alpha; hepatocyte nuclear factor 1-alpha-A; HNF-1-alpha; HNF-1-alpha-A; HNF-1A; HNF-1A-A; HNF1; HNF1 homeobox A; interferon production regulator factor; LF-B1 hepatic nuclear factor (HNF1): albumin proximal factor also TCF1; LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1; LFB1; liver-specific transcription factor LF-B1; MODY3; TCF-1; TCF-1-A; TCF1; transcription factor 1; Transcription factor 1 hepatic; Transcription factor 1, hepatic; transcription factor 1, transcription factor LFB1 /HNF1; transcription factor 1-A; xlFB1A
AI323641; Hnf-1; HNF-1A; HNF1; hnf1-a; HNF1-alpha; HNF1[a]; HNF1A; hnf1a-a; Hnf1alpha; I79_010330; IDDM20; LF-B1; LFB1; lfb1a; LFB1a1; MODY3; TCF-1; TCF1; tcf1-A