Peptide sequence: ITISQQLGLE LSTVSNFFMN ARRRSLDKWQ DEGSSNSGNS SSSSSTCTKA
Sequence homology: Cow: 93%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 86%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%
Hepatocyte nuclear factor 6 is a CUT homeobox family protein which is a transcription factor and contains a CUT DNA-binding domain and a homeobox DNA-binding domain. It is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. HNF6 is a ligand of the FOXM1 transcription factor network. HNF6, along with HNF4, controls gene expression in the liver. The expression levels of HNF6 and HNF4 rise steadily during development and that up- or down regulation of HNF6 and HNF4 expression generate premature or delayed expression of the g6pc gene.
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Protein Aliases: hepatic nuclear factor 6; Hepatocyte nuclear factor 6; hepatocyte nuclear factor 6 alpha; hepatocyte nuclear factor 6, alpha; HNF-3/forkhead homolog 12; HNF-6; hnf6; One cut domain family member 1; one cut domain, family member 1; one cut domain, family member 1, like; one cut domain, family member 1-like; One cut homeobox 1; transcription factor; hepatocyte nuclear factor 6; hnf-6
Gene Aliases: BOS_10950; D9Ertd423e; Hfh12; HNF-6; HNF-6a; HNF6; HNF6A; Hnf6b; OC-1; Oc1; ONECUT1; onecut1l; zgc:65904; zgc:77450