Proteintech

HO-1/HMOX1 Polyclonal Antibody

13 References

View all (35) HO-1 antibodies

Datasheet

Protocols

Tech Support

Datasheet

Protocols

Tech Support

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HO-1/HMOX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney tissue slide using 27282-1-AP (HO-1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

HO-1/HMOX1 Antibody in Western Blot (WB) — Mouse spleen tissue were subjected to SDS PAGE followed by western blot with 27282-1-AP (HO-1/HMOX1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

Product Details

27282-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	View 13 publications 13 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:500	-

Product Specifications
Species Reactivity	Human, Mouse
Published species	Human, Mouse, Pig, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	HO-1/HMOX1 Fusion Protein Ag26172 (151-288 aa encoded by BC001491)
Conjugate	Unconjugated
Form	Liquid
Concentration	0.2 mg/mL
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: AQKALDLPS SGEGLAFFTF PNIASATKFK QLYRSRMNSL EMTPAVRQRV IEEAKTAFLL NIQLFEELQE LLTHDTKDQS PSRAPGLRQR ASNKVQDSAP VETPRGKPPL NTRSQAPLLR WVLTLSFLVA TVAVGLYAM (151-288 aa encoded by BC001491)

Target Information

Heme oxygenase (HO) is a microsomal enzyme that catalyzes the oxidation of heme to the antioxidant molecules, biliverdin and carbon monoxide. HO consists of two homologous isozymes, an inducible HO-1 and a constitutively expressed HO-2. HO-1 is induced by a wide variety of stimuli including conditions of oxidative stress, inflammatory agents, transforming growth factor beta and heat shock. The increase in expression of HO-1 is thought to be a cellular defense mechanism against oxidative stress since elevated HO could eventually generate more bilirubin, an anti-oxidant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A Novel Derivative of the Natural Product Danshensu Suppresses Inflammatory Responses to Alleviate Caerulein-Induced Acute Pancreatitis.

Frontiers in immunology

Ren Z,Li H,Zhang M,Zhao Y,Fang X,Li X,Chen W,Zhang H,Wang Y,Pan LL,Sun J

Thu Oct 03 00:00:00 EDT 2019

The Phenolic Components of Gastrodia elata improve Prognosis in Rats after Cerebral Ischemia/Reperfusion by Enhancing the Endogenous Antioxidant Mechanisms.

Oxidative medicine and cellular longevity

Shi A,Xiang J,He F,Zhu Y,Zhu G,Lin Y,Zhou N

Fri Sep 21 00:00:00 EDT 2018

Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway.

Molecular medicine reports

Xue S,He W,Zeng X,Tang Z,Feng S,Zhong Z,Xiong Y,Wang Y,Ye Q

Sun Jul 01 00:00:00 EDT 2018

Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Gao W,Xiao C,Hu J,Chen B,Wang C,Cui B,Deng P,Yang J,Deng Z

Sun Jul 01 00:00:00 EDT 2018

Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity.

Neuroscience

Pu D,Zhao Y,Chen J,Sun Y,Lv A,Zhu S,Luo C,Zhao K,Xiao Q

Fri Jun 15 00:00:00 EDT 2018

Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.

Free radical biology & medicine

Li H,Tang Z,Chu P,Song Y,Yang Y,Sun B,Niu M,Qaed E,Shopit A,Han G,Ma X,Peng J,Hu M,Tang Z

Sun May 20 00:00:00 EDT 2018

Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.

Free radical biology & medicine

Li H,Tang Z,Chu P,Song Y,Yang Y,Sun B,Niu M,Qaed E,Shopit A,Han G,Ma X,Peng J,Hu M,Tang Z

Sun May 20 00:00:00 EDT 2018

Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.

ACS chemical neuroscience

Dai C,Ciccotosto GD,Cappai R,Wang Y,Tang S,Hoyer D,Schneider EK,Velkov T,Xiao X

Wed Apr 18 00:00:00 EDT 2018

Methylphenidate ameliorates hypoxia-induced mitochondrial damage in human neuroblastoma SH-SY5Y cells through inhibition of oxidative stress.

Life sciences

Zhu M,Tian Y,Zhang H,Ma X,Shang B,Zhang J,Jiao Y,Zhang Y,Hu J,Wang Y

Thu Mar 15 00:00:00 EDT 2018

Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.

International journal of molecular sciences

Tang X,Liu B,Wang X,Yu Q,Fang R

Wed Mar 14 00:00:00 EDT 2018

Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.

International immunopharmacology

Jia YN,Lu HP,Peng YL,Zhang BS,Gong XB,Su J,Zhou Y,Pan MH,Xu L

Thu Mar 01 00:00:00 EST 2018

Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.

International immunopharmacology

Shi A,Shi H,Wang Y,Liu X,Cheng Y,Li H,Zhao H,Wang S,Dong L

Mon Jan 01 00:00:00 EST 2018

Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model.

World journal of gastroenterology

Sang L,Wang XM,Xu DY,Sang LX,Han Y,Jiang LY

Thu Dec 21 00:00:00 EST 2017

Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells.

Scientific reports

Sun Y,Yuan X,Zhang F,Han Y,Chang X,Xu X,Li Y,Gao X

Tue Sep 12 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: heat shock protein, 32-kD; heme orygenase 1; heme oxygenase (decycling) 1; Heme oxygenase 1; Heme oxygenase 1 soluble form; hemoxygenase; HO-1; P32 protein

Gene Aliases: HMOX1; HO; HO1