Applications | Tested Dilution | Publications |
---|---|---|
Immunocytochemistry (ICC/IF) |
1:50-1:500 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Pig, Rat |
Host/Isotype |
Mouse / IgG2a |
Class |
Monoclonal |
Type |
Antibody |
Clone |
2D10A5 |
Immunogen |
Full length HO-1 protein. |
Conjugate |
CoraLite®488
|
Form |
Liquid |
Concentration |
2 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS, pH 7.3, with 0.5% BSA, 50% glycerol |
Contains |
0.05% Proclin 300 |
Storage conditions |
-20° C, store in dark |
Heme oxygenase (HO) is a microsomal enzyme that catalyzes the oxidation of heme to the antioxidant molecules, biliverdin and carbon monoxide. HO consists of two homologous isozymes, an inducible HO-1 and a constitutively expressed HO-2. HO-1 is induced by a wide variety of stimuli including conditions of oxidative stress, inflammatory agents, transforming growth factor beta and heat shock. The increase in expression of HO-1 is thought to be a cellular defense mechanism against oxidative stress since elevated HO could eventually generate more bilirubin, an anti-oxidant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: heat shock protein 32; heat shock protein, 32-kD; heme orygenase 1; heme oxygenase (decycling) 1; heme oxygenase (decyclizing) 1; Heme oxygenase 1; hemoxygenase; HO-1; HSP32; P32 protein
Gene Aliases: bK286B10; D8Wsu38e; Hemox; Heox; HEOXG; Hmox; HMOX1; HMOX1D; HO; HO-1; HO1; HSP32
UniProt ID: (Human) P09601, (Pig) P32394, (Rat) P06762, (Mouse) P14901
Entrez Gene ID: (Human) 3162, (Pig) 445512, (Rat) 24451, (Mouse) 15368
Molecular Function:
oxygenase
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