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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the internal region of human HOXA11/D11|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
homeo box 1I; homeo box 4F; homeo box A11; homeo box D11; homeobox protein Hox-1.9; homeobox protein Hox-1I; homeobox protein Hox-4.6; homeobox protein Hox-4F; homeobox protein Hox-5.5; homeobox protein Hox-A11; homeobox protein Hox-D11; homeobox protein HOXA11; Hox-4.6, mouse, homolog of; HOX11
E230017H14Rik; Hox-1.9; Hox-4.6; Hox-5.4; Hox-5.5; HOX1; HOX1I; HOX4; HOX4F; Hoxa-11; HOXA11; Hoxd-11; HOXD11; RUSAT1