HOXD9 is the sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.
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Protein Aliases: homeo box D9; Homeobox protein Hox-4C; Homeobox protein Hox-5.2; Homeobox protein Hox-D9; Hox-4.3, mouse, homolog of
Gene Aliases: Hox-4.3; Hox-5.2; HOX4; HOX4C; HOXD9
UniProt ID: (Human) P28356
Entrez Gene ID: (Human) 3235