|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 24 and 117 of HP1 gamma|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28454 targets HP1 gamma in WB applications and shows reactivity with Human samples.
The PA5-28454 immunogen is a synthetic peptide corresponding to a region within amino acids 24 and 117 of HP1 gamma.
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: chromobox homolog 3 (HP1 gamma homolog; chromobox homolog 3 (HP1 gamma homolog, Drosophila); Chromobox protein homolog 3; Drosophila); HECH; Heterochromatin protein 1 homolog gamma; heterochromatin protein HP1 gamma; heterochromatin-like protein 1; HP1 gamma; HP1 gamma homolog; HP1-GAMMA; HP1Hs-gamma; Modifier 2 protein
Gene Aliases: CBX3; HECH; HP1-GAMMA; HP1Hs-gamma
UniProt ID: (Human) Q96CD7
Entrez Gene ID: (Human) 11335
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