The protein is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway.
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Protein Aliases: HGPRT; HGPRTase; HPRT 1; Hypoxanthine-guanine phosphoribosyltransferase; hypoxanthine-guanine phosphoribosyltransferase 1; testicular tissue protein Li 89
Gene Aliases: HGPRT; HPRT; HPRT1
UniProt ID: (Human) P00492
Entrez Gene ID: (Human) 3251
Molecular Function: glycosyltransferase