MA1-10890 detects Heat Shock Protein 70/Heat Shock Cognate Protein 70 in human, mouse, rat, rabbit, monkey, guinea pig, hamster, chicken, bovine, canine, ovine, porcine, fish, Xenopus, Drosophila, C. elegans, and plant samples.
MA1-10890 has been successfully used in Western blot, immunohistochemistry, immunoprecipitation and flow cytometry procedures. By Western blot, MA1-10890 is specific for the ~72 kDa Heat Shock Protein 70/Heat Shock Cognate Protein 70 protein. Positive control of HeLa cell lysate recommended.
MA1-10890 immunogen is purified recombinant Hsp70/Hsc70.
Hsp70 genes, members of a multigene family, encode heat-inducible 70 kDa heat-shock proteins that function as molecular chaperones. They have been identified in most organelles of eukaryotic cells as well as in bacteria. The N-terminus of Hsp70 binds ATP with high affinity and the C-terminus binds proteins and polypeptides. Hsp70s bind nascent ploypeptides as well as partially folded intermediates of proteins, thus preventing their aggregation and/or misfolding. Binding of ATP triggers a conformational change that results in the release of bound protein. Hsp70s function in protein synthesis, protein folding and oligomerization, and protein transport.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AAG2; aging-associated protein 2; constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; FAM10A1; Heat shock 70 kDa protein 8; heat shock 70kd protein 10; heat shock 70kd protein 10 (HSC71); heat shock 70kD protein 8; heat shock 70kD protein binding protein; heat shock 70kDa protein 8; heat shock cognate 70; heat shock cognate 71 kD protein; Heat shock cognate 71 kDa protein; heat shock cognate 71 kDa protein-like protein; heat shock cognate hsc73; heat shock cognate protein 54; Heat shock cognate protein 70; heat shock protein 70 cognate; heat shock protein 8; heat shock protein A8; heat shock protein cognate 70; HIP; Hsc70 ATPase; hsc70-interacting protein; Hsp70-interacting protein; LAP-1; Lipopolysaccharide-associated protein 1; LPS-associated protein 1; N-myristoyltransferase inhibitor protein 71; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; renal carcinoma antigen NY-REN-33; SNC6; suppression of tumorigenicity 13 protein
Gene Aliases: 2410008N15Rik; BOS_14437; HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; Hsc73; HSP71; HSP73; HSPA10; HSPA8; LAP-1; LAP1; NIP71