|Tested species reactivity||Mammal|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant HSP60 protein.|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay dependent.|
|Western Blot (WB)||Assay dependent.|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Two pseudogenes, both located on chromosome 8, have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Analysis of mutant DNA polymerase gamma in patients with mitochondrial DNA depletion.
MA1-35434 was used in western blot to study the role of mutant DNA polymerase gamma in patients with depletion of mitochondrial DNA
|Taanman JW,Rahman S,Pagnamenta AT,Morris AA,Bitner-Glindzicz M,Wolf NI,Leonard JV,Clayton PT,Schapira AH||Human mutation (30:248)||2009|
Tissue microarray analysis of FAS, Bcl-2, Bcl-x, ER, PgR, Hsp60, p53 and Her2-neu in breast carcinoma.
MA1-35434 was used in immunohistochemistry to investigate immunohistological markers in human breast carcinomas using tissue microarray
|Sebastiani V,Botti C,Di Tondo U,Visca P,Pizzuti L,Santeusanio G,Alo PL||Anticancer research (26:2983)||2006|
Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes.
MA1-35434 was used in immunohistochemistry to investigate the therapeutic efficacy of p38 MAPKs in p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mouse model
|Medicherla S,Protter AA,Ma JY,Mangadu R,Almirez R,Koppelman B,Kerr I,Navas TA,Movius F,Reddy M,Liu YW,Luedtke G,Perumattam J,Mavunkel B,Dugar S,Schreiner GF||The Journal of pharmacology and experimental therapeutics (318:99)||2006|
Heat shock proteins 60 and 70 expression of cutaneous lichen planus: comparison with normal skin and psoriasis vulgaris.
MA1-35434 was used in immunohistochemistry to investigate the different expression of heat shock protein -60,-70 in normal skin and psoriasis vulgaris
|Bayramgürler D,Ozkara SK,Apaydin R,Erçin C,Bilen N||Journal of cutaneous pathology (31:586)||2004|
Immunohistochemical study of heat shock proteins 27, 60 and 70 in the normal human adrenal and in adrenal tumors with suppressed ACTH production.
MA1-35434 was used in immunohistochemistry to investigate the expression of heat shock proteins in normal and tumoral adrenal glands
|Pignatelli D,Ferreira J,Soares P,Costa MJ,Magalhães MC||Microscopy research and technique (61:315)||2003|
In situ immunohistochemical study of Bcl-2 and heat shock proteins in human corneal endothelial cells during corneal storage.
MA1-35434 was used in immunohistochemistry to investigate the expression of Bcl-2 and heat shock proteins in human corneal endothelial cells in organ Culture
|Gain P,Thuret G,Chiquet C,Dumollard JM,Mosnier JF,Campos L||The British journal of ophthalmology (85:996)||2001|