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|Tested species reactivity||Eubacteria, Mammals|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant HSP60 protein.|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay dependent.|
|Western Blot (WB)||Assay dependent.|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 3 publications below|
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Two pseudogenes, both located on chromosome 8, have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
"Toxic memory" via chaperone modification is a potential mechanism for rapid Mallory-Denk body reinduction.
MA1-35433 was used in western blot to study the role of chaperone modification in rapid Mallory-Denk body reinduction
|Strnad P,Tao GZ,So P,Lau K,Schilling J,Wei Y,Liao J,Omary MB||Hepatology (Baltimore, Md.) (48:931)||2008|
Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models.
MA1-35433 was used in western blot to the role of keratin mutations in liver fibrosis in different mouse models
|Strnad P,Tao GZ,Zhou Q,Harada M,Toivola DM,Brunt EM,Omary MB||Gastroenterology (134:1169)||2008|
Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement.
MA1-35433 was used in western blot to study the role of transglutaminase 2 in Mallory body inclusion formation and injury-associated liver enlargement
|Strnad P,Harada M,Siegel M,Terkeltaub RA,Graham RM,Khosla C,Omary MB||Gastroenterology (132:1515)||2007|