This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated. View Details
MA1-10889 detects Heat Shock Protein 70 in human, mouse, rat, rabbit, monkey, guinea pig, hamster, chicken, bovine, canine, ovine, porcine, fish, Drosophila and C. elegans samples and does not cross-react with Hsc70.
MA1-10889 has been successfully used in Western blot, immunohistochemistry, immunoprecipitation, ELISA and flow cytometry procedures. By Western blot, MA1-10889 is specific for the ~70 kDa Heat Shock Protein 70 protein.
MA1-10889 immunogen is human Hsp70 purified from HeLa cells, corresponding to amino acids 436-503.
HSP70 is a Heat shock protein (HSP) which are expressed in response to various biological stresses, including high temperatures. There are several major families of HSPs that include HSP70, there are HSP90 and HSP100. The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. Further, HSP70 is encoded by an intronless gene and, in conjunction with other heat shock proteins, HSP70 stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and organelles. HSP70 is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The HSP70 gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 68 kDa heat shock protein; 70 kda heat shock protein-2; chaperone; dnaK-type molecular chaperone HSP70-1; epididymis secretory protein Li 103; heat shock 70 kD protein 2; Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; Heat shock 70 kDa protein 3; heat shock 70kD protein 1A; heat shock 70kDa protein 1A; heat shock 70kDa protein 1B; heat shock protein 70-1; heat shock protein, 70 kDa 3; heat shock-induced protein; heat shock-induced protein, Hspa70; heat-shock 70-kilodalton protein 1B; Hsp68; HSP70-1; HSP70-1/HSP70-2; HSP70-1A; HSP70-2; HSP70.1; HSP70.1/2; HSP70.1/HSP70.2; HSP70.2; HSP70.3; HSP70I; HSP72; HSPA1; inducible heat shock protein 70
Gene Aliases: BOS_21593; HEL-S-103; hsp68; HSP70-1; HSP70-1A; HSP70-2; Hsp70-3; HSP70.1; Hsp70.3; Hsp70A1; HSP70I; HSP72; HSPA1; HSPA1A; HSPA1B; HSPA2; HSX70; SBAB-707F1.4; si:ch73-46h18.6; si:dkeyp-69e1.1; zgc:174006