This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
This antibody recognizes the epitope EEEVE within N-terminal part of ubiquitously expressed Hsp90 alpha and Hsp90 beta proteins, with calculated MW of 84.7 kDa and 83.3 kDa, respectively. However, it migrates as 90 kDa bands under reducing SDS-PAGE conditions.
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 and mitochondria (Chen et al., 2005 ).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; Heat shock 84 kDa; Heat shock 86 kDa; heat shock 90 kDa protein; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein 1, beta; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 1, beta; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein HSP 90-alpha; Heat shock protein HSP 90-beta; heat shock protein, 1; heat shock protein, 84 kDa 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; HSP; HSP 84; HSP 86; HSP 90; HSP86; HSP90-beta; LAP-2; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38; retinal degeneration slow protein; TSTA; Tumor-specific transplantation 84 kDa antigen; Tumor-specific transplantation 86 kDa antigen
Gene Aliases: 86kDa; 89kDa; 90kDa; AL022974; AL024080; AL024147; C81438; D6S182; EL52; HEL-S-65p; hsp4; HSP84; Hsp84-1; HSP86; Hsp86-1; Hsp89; HSP89A; Hsp90; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSP90N; HSPC1; HSPC2; HSPCA; HSPCAL1; HSPCAL4; HSPCB; HSPN; LAP-2; LAP2
Molecular Function: Hsp90 family chaperone